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	Provedor de dados BABT (10) BJMBR (2) BJPS (2) Anais da ABC (AABC) (1) Autor Holanda,Cecília Maria de Carvalho Xavier (2) Santos-Oliveira,Ralph (2) Aragão,Cícero Flávio Soares (1) Araújo,Elaine Bortoleti de (1) Barbosa,Vanessa Santos de Arruda (1) Bernardo-Filho,M. (1) Bernardo-Filho,Mario (1) Bernardo-Filho,Mário (1) Biancardi,Rodrigo (1) Boasquevisque,Edson Mendes (1) Britton,Keith E. (1) Buchpiguel,C.A. (1) Carneiro-Leão,Ana Maria A. (1) Carvalho,J.J. (1) Catanho,Maria Teresa Jansen de Almeida (1) Clemente,Gonçalo dos Santos (1) Colturato,Maria Tereza (1) Das,Satya (1) Das,Satya S. (1) De-Paula,E.F. (1) Mais... Palavra-chave Radiopharmaceuticals (15) Drug interaction (4) 99mTc- ciprofloxacin (2) Blood elements (2) Inflammation (2) Nuclear medicine (2) Radiolabelled anti-infectives (2) 125I-erythropoietin/biological evaluation (1) 125I-erythropoietin/synthesis (1) 18-FDG/utilization (1) 99mTc-MDP (1) Adenocarcinomas (1) Antimalarial drugs (1) Antitumoral drug (1) Aptamers (1) Artemisinin (1) Bioavailability (1) Biodistribution (1) Cancer (1) Chromatography (1) Mais... Tipo do documento Info:eu-repo/semantics/article (15) Ano 2015 (1) 2011 (1) 2010 (1) 2008 (3) 2007 (2) 2006 (1) 2005 (2) 2002 (3) 1998 (1) Mais... País Brazil (15) Idioma Inglês (15)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 15 Primeira ... 1 ... Última Activities, procedures and doses in pediatric patients due to radiopharmaceuticals BABT Oliveira,Silvia Maria Velasques de; Boasquevisque,Edson Mendes; Santos,Felipe Sima dos; Biancardi,Rodrigo. An investigation performed between 2003 and 2005 in sixteen selected public and private institutions in Northeast, Southeast and South geographical regions of Brazil evaluated average organ doses and effective doses in 2,411 pediatric patients due to diagnostic procedures with radiopharmaceuticals. For 1 year, effective doses were greater than literature. For 5 years, differences were noticed between present work and literature for bone scintigraphy, thyroid scintigraphy and 67Ga citrate scintigraphy. These differences may be attributed to the uncertainties in internal dose calculations. High absorved doses in bone surfaces of children due to 67Ga citrate and bone scintigraphy should be evaluated accordingly. Current protocols used recommend standardized... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pediatrics; Oncology; Dosimetry; Radiopharmaceuticals; Nuclear medicine; Radiation protection. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700019 Advances in bacterial specific imaging BABT Wareham,David; Michael,J.; Das,Satya. Nuclear medicine is a powerful diagnostic technique able to detect inflammatory foci in human disease. A wide range of agents have been evaluated for their ability to distinguish lesions due to microbial infection from those due to sterile inflammation. Advances continue to be made on the use of radiolabelled antibiotics which as well as being highly specific in the diagnosis of infection may be useful in monitoring the treatment and course of disease. Here we provide an update on in-vitro and clinical studies with a number of established and novel radiopharmaceuticals Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Infection specific imaging; Radiolabelled anti-infectives; 99mTc- ciprofloxacin. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700021 Alternative chromatographic system for the quality control of lipophilic technetium-99m radiopharmaceuticals such as [99mTc(MIBI)6]+ BJMBR Faria,D.P.; Buchpiguel,C.A.; Marques,F.L.N.. Knowledge of the radiochemical purity of radiopharmaceuticals is mandatory and can be evaluated by several methods and techniques. Planar chromatography is the technique normally employed in nuclear medicine since it is simple, rapid and usually of low cost. There is no standard system for the chromatographic technique, but price, separation efficiency and short time for execution must be considered. We have studied an alternative system using common chromatographic stationary phase and alcohol or alcohol:chloroform mixtures as the mobile phase, using the lipophilic radiopharmaceutical [99mTc(MIBI)6]+ as a model. Whatman 1 modified phase paper and absolute ethanol, Whatman 1 paper and methanol:chloroform (25:75), Whatman 3MM paper and ethanol:chloroform... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Technetium-99m; Quality control; Chromatography. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001000007 Aptamer-based therapeutics and their potential in radiopharmaceutical design BABT Ferreira,Catia S. M.; Missailidis,Sotiris. Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications. These range from inhibition of receptors and enzymes to the identification of small molecules in sensor applications, and from the development of targeted therapeutic to the design of novel diagnostic and imaging agents. Furthermore, aptamers have been designed for targets that cover a wide range of diseases, from HIV to tropical diseases, cancer and inflammation. Their easy development and flexibility of use and manipulation, offers further potential. In this paper we review their selection and consider some of the recent applications of aptamers in the design of radiopharmaceuticals for the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aptamers; Radiopharmaceuticals; SELEX; Radiolabeling; Medical imaging. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600008 Comparative biodistribution profile of [131I]VIP and [131I]VIP10-28 BABT Colturato,Maria Tereza; Muramoto,Emiko; Araújo,Elaine Bortoleti de. Various tumor cells express significantly higher amounts of VIP receptors (VIPR) that provided the basis for the clinical use of radiolabeled VIP for the in vivo localization of tumors. This work studied the labeling of VIP and VIP10-28 with iodine-131 to compare the biological distribution of the labeled compounds in Nuce mice and the affinity for tumor cells. Both VIP and VIP10-28 peptides contain two tyrosine residues, in positions 10 and 22, that are theoretically equally susceptible to radioiodination employing oxidative electrophilic substitution using oxidizing agents like Chloramine T. Radiochemical purity of the reaction mixture was determined by electrophoresis and HPLC. The VIP peptide and the fragment were labeled with radioiodine with good... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Protein radioiodination; VIP; VIP10-28; Adenocarcinomas. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700012 Drug interaction with radiopharmaceuticals: effect on the labeling of red blood cells with technetium-99m and on the bioavailability of radiopharmaceuticals BABT Gomes,Maria Luisa; Oliveira,Marcia B. Nunes de; Bernardo-Filho,Mario. The evidence that natural and synthetic drugs can affect radiolabeling or bioavailability of radiopharmaceuticals in setting of nuclear medicine clinic is already known. However, this drug interaction with radiopharmaceuticals (DIR) is not completely understood. Several authors have described the effect of drugs on the labeling of blood elements with technetium-99m (99mTc) and on the biodistribution of radiopharmaceuticals. When the DIR is known, if desirable or undesirable, the natural consequence is a correct diagnosis. However, when it is unknown, it is undesirable and the consequences are the possibility of misdiagnosis and/or the repetition of the examination with an increase of radiation dose to the patient. The possible explanation to the appearance... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug interaction; Blood elements; Radiopharmaceuticals; Bioavailability. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500020 Effect of antimalarial drugs on the bioavailability of the methylenediphosphonic acid labeled with technetium99m (99mTc-MDP) in Wistar rats BABT Holanda,Cecília Maria de Carvalho Xavier; Leite,Rodrigo de Carvalho Holanda; Nunes,Reginauro Alves da Silva; Oliveira,Harina Alves de; Catanho,Maria Teresa Jansen de Almeida; Souza,Grace Mary Lima de; Bernardo-Filho,Mário. The aim of this work was to study the effect of antimalarial drugs on the bioavailability of 99mTc-MDP in rats. Mefloquine (MQ) and artemisinin (AM) were administered in two treated groups (T) and sorbitol in control group (C) for 7 days. Then, 99mTc-MDP was injected in all groups and %ATI was calculated. A significant increase of %ATI in MQ group, from C to T, occurred in spleen (0.35±0.10to0.58±0.13), liver (1.69±0.28to3.31±0.07) and blood (0.79±0.17to2.09±0.53). The %ATI increased significantly in AM group:femur (2.76±0.59to5.98±0.70), liver (1.69±0.28to4.59±0.68), lungs (0.29±0.05to6.22±0.86), spleen (0.35±0.10 to0.86±0.15) and blood (0.79±0.17 to4.65 ±0.74). A significant decrease of %ATI occurred in MQ group:bladder (0.75±0.07to0.26±0.05), stout... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug interaction; Radiopharmaceuticals; 99mTc-MDP; Antimalarial drugs; Mefloquine; Artemisinin. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000300004 Effect of paclitaxel (Taxol®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in female Wistar rats BABT Holanda,Cecília Maria de Carvalho Xavier; Oliveira,Elias Herculano de; Rocha,Louisianny Guerra da; Barbosa,Vanessa Santos de Arruda; Spyrides,Maria Helena Constantino; Aragão,Cícero Flávio Soares; Medeiros,Aldo da Cunha. The evidence that natural or synthetic drugs can affect the biodistribution of radiopharmaceuticals (radiobiocomplexes) in setting of nuclear medicine clinic is already known. We studied the effect of Paclitaxel, an anti-neoplastic agent for the treatment of solid tumors, on the biodistribution of Na99mTcO4 in female rats. Paclitaxel (1mg/mL/week) was administered into animals in single dose during 3 weeks, with interval of 1 week among them. The control group received NaCl 0.9% solutions by the same via. One hour after the last dose, it was injected Na99mTcO4 in the animals. The percentage of activity per gram (%ATI/g) and biochemical and hematological determinations were performed. A significant increase were found in alanine aminotransferase, aspartate... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paclitaxel; Drug interaction; Radiopharmaceuticals; Na99mTcO4; Antitumoral drug; Cancer. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700031 Importance of the nutritional status for the interpretation of nuclear medicine examinations BABT Moura,Egberto Gaspar de; Passos,Magna Cottini Fonseca. Malnutrition is very prevalent in the Third World, but still in developing Countries and is found in certain communities in developed Countries. Several laboratories examinations are affected by malnutrition. Recently, gestational or neonatal malnutrition were considered to contribute to the development of chronic diseases in adulthood, this phenomena was named programming or metabolic imprinting. Similar consideration were suggested for Nuclear Medicine examinations. Here we review the literature about this aspect and present our own data showing changes in biodistribution of a radiopharmaceutical compound in different animal models of adult malnutrition or caused by maternal malnutrition programming. Tipo: Info:eu-repo/semantics/article Palavras-chave: Programming; Nuclear Medicine; Malnutrition; Biodistribution; Radiopharmaceuticals. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500021 In vitro radioautographic studies of the biodistribution of radiopharmaceuticals on blood elements BJMBR Ripoll-Hamer,E.; De-Paula,E.F.; Freitas,L.C.; Pereira,M.J.S.; Fonseca,L.M.; Gutfilen,B.; Carvalho,J.J.; Pôrto,L.C.M.S.; Bernardo-Filho,M.. In the present study we evaluated the binding of the radiopharmaceuticals sodium pertechnetate (Na 99mTcO4), methylenediphosphonic acid (99mTc-MDP) and glucoheptonate acid (99mTc-GHA) to blood elements using centrifugation and radioautographic techniques. Heparinized blood was incubated with the labelled compounds for 0, 1, 2, 3, 4, 6 and 24 h. Plasma (P) and blood cells (BC) were isolated and precipitated with 5% trichloroacetic acid (TCA), and soluble (SF) and insoluble fractions (IF) were separated. Blood samples were prepared (0 and 24 h) and coated with LM-1 radioautographic emulsions and percent radioactivity (%rad) in P and BC was determined. The binding of Na 99mTcO4 (%rad) to P was 61.2% (0 h) and 46.0% (24 h), and radioautography showed 63.7% (0... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radioautography; Radiopharmaceuticals; Blood elements. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200014 Infection imaging with radiopharmaceuticals in the 21st century BABT Das,Satya S.; Hall,Anne V.; Wareham,David W.; Britton,Keith E.. Infection continues to be a major cause of morbidity and mortality worldwide. Nuclear medicine has an important role in aiding the diagnosis of particularly deep-seated infections such as abscesses, osteomyelitis, septic arthritis, endocarditis, and infections of prosthetic devices. Established techniques such as radiolabelled leucocytes are sensitive and specific for inflammation but do not distinguish between infective and non-infective inflammation. The challenge for Nuclear medicine in infection imaging in the 21st century is to build on the recent trend towards the development of more infection specific radiopharmaceuticals, such as radiolabelled anti-infectives (e.g. 99mTc- ciprofloxacin). In addition to aiding early diagnosis of infection, through... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Imaging; Infection; Inflammation; Radiolabelled anti-infectives; 99mTc- ciprofloxacin. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500005 Influence of radiation on endotoxin test using the PTS TM for 18-FDG radiopharmaceutical BJPS Santos-Oliveira,Ralph. F-18 FDG (2-[18-F] fluoro-2-deoxy-D-glucose) is the most frequently used radiopharmaceutical for PET and PET CT imaging exams. The FDA recently approved the use of the PTS TM (Portable Test System) as an alternative to the standard test proposed by the United States Pharmacopeia using the LAL (Limulus Amebocyte Lysates), that takes longer to perform (about 1h) than the PTS TM (15 min). Recent studies have demonstrated that radiation could interfere with the PTS TM test. In order to study the effects of radiation on the PTS TM test and/or equipment, 27 batches of F-18 FDG produced in the Nuclear Engineering Institute were analyzed. The results showed that no direct correlation with radiation was found in any of the cases. Tipo: Info:eu-repo/semantics/article Palavras-chave: 18-FDG/utilization; Radiopharmaceuticals; Nuclear medicine; Endotoxin test; Portable Test System/radiation effects. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300019 Radiopharmaceuticals drug interactions: a critical review Anais da ABC (AABC) Santos-Oliveira,Ralph; Smith,Sheila W.; Carneiro-Leão,Ana Maria A.. Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment. As the use of image has been increased, so has the use of prescription medications. These trends increase the risk of interactions between medications and radiopharmaceuticals. These interactions which have an impact on image by competing with the radiopharmaceutical for binding sites for example can lead to false negative results. Drugs that accelerate the metabolism of the radiopharmaceutical can have a positive impact (i.e. speeding its clearance) or, if repeating image is needed, a negative impact. In some cases, for example in cardiac image among patients taking doxirubacin, these... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Radiopharmacy; Drug interaction; Systematic review. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000400008 Radiopharmaceuticals for imaging chronic lymphocytic inflammation BABT Malviya,Gaurav; Vries,Erik F.J. de; Dierckx,Rudi A.; Signore,Alberto. In the last few decades, a number of radiopharmaceuticals for imaging inflammation have been proposed that differ in their specificity and mechanism of uptake in inflamed foci as compared to the traditional inflammation imaging agents. Radiolabelled cytokines represent a reliable tool for the preclinical diagnosis of chronic inflammatory processes, even before anatomical and functional changes occur in affected tissues. Moreover, the introduction of radiolabelled monoclonal antibodies and sophisticated technique like PET/CT now make the field of inflammation imaging highly specific and accurate. In this review, different approaches of the established and experimental radiopharmaceuticals for imaging of chronic inflammation are discussed. Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Inflammation; Molecular Imaging. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600002 Synthesis and biological evaluation of 125I-erythropoietin as a potential radiopharmaceutical agent for tumours BJPS Clemente,Gonçalo dos Santos; Duarte,Vera Lúcia Serra. Erythropoietin (EPO) is a glycoprotein hormone responsible for regulating erythropoiesis. Expression of EPO and EPO receptors (EPOr) has recently been demonstrated in some neoplastic cell lines and tumours, suggesting a potential new target for therapy. In this work, EPO was labeled with iodine-125 using the lactoperoxidase method, known to prevent damage to protein during radioiodination, and labeling conditions were optimized. In vitro stability studies have shown that 125I-EPO is radiochemically stable for 20 days after radiolabeling. In vitro cell binding studies have demonstrated very low binding (<2%) of EPO to normal and neoplastic cell lines tested. As expected, the biodistribution in healthy mice exhibited comparatively high rates of fixation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Erythropoietin (EPO); Glycoprotein hormone; 125I-erythropoietin/synthesis; 125I-erythropoietin/biological evaluation; Erythropoiesis/regulation; Radiopharmaceuticals; Iodine-125/labelled; EPO expressive tumours. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100010 Registros recuperados: 15 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco